Award
NIH Reporter #5P50HD118717-02
Circuit pathophysiology, phenotypic heterogeneity and translational electrophysiological biomarkers in mouse models of FXS
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$524,473.00
Ceiling
$524,473.00
Awarded
September 04, 2026
Identifier
5P50HD118717-02
NIH grant awarded to Cincinnati Children's Hospital Medical Center for research on electrophysiological biomarkers and phenotypic heterogeneity in mouse models of Fragile X Syndrome, aiming to identify novel drug targets.
Description
This project focuses on the circuit pathophysiology, phenotypic heterogeneity, and development of translational electrophysiological biomarkers in mouse models of Fragile X Syndrome (FXS). The research team has identified neurophysiological signatures of FXS, including EEG biomarkers of gamma power and cortical synchronization, which are conserved across mice and humans. The study aims to define circuit mechanisms, develop EEG biomarkers, analyze phenotypic heterogeneity, and evaluate drug effects, with the goal of identifying novel biomarker-based drug targets for FXS treatment.