Award
NIH Reporter #5R01AI134834-07
Gene regulation mechanisms involving the inactive X in B cells during lupus disease
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$609,688.00
Ceiling
$609,688.00
Awarded
August 24, 2026
Identifier
5R01AI134834-07
This award supports research into the genetic and epigenetic mechanisms by which chronic inflammation affects X chromosome gene expression in B cells, contributing to female-biased lupus disease. The study will provide insights into autoimmune disease pathways and potential therapeutic targets.
Description
Investigation of how chronic inflammation from elevated type I interferons impacts gene expression from the X chromosomes in B cells, focusing on female-biased lupus disease. The project aims to reveal genes predisposed to epigenetic alterations and aberrant expression related to lupus.