Award
NIH Reporter #1R03AI203321-01
Generation of C5aR-TurboID mice
Recipient
Boston University Medical Campus
Award Amount
$81,750.00
Ceiling
$81,750.00
Awarded
August 27, 2026
Identifier
1R03AI203321-01
Grant awarded to Boston University Medical Campus to generate genetically engineered mouse models for studying complement receptors C5AR1 and C5AR2 in immune regulation and inflammatory diseases.
Description
The project aims to generate mouse models with tissue-specific overexpression of C5AR1 and C5AR2 fused to TurboID for proximity labeling and interactome studies. These models will facilitate functional analysis of complement receptors involved in immune responses and tissue homeostasis.