Award
National Institute of Neurological Disorders and Stroke 5R01NS128080-04
Mechanisms of migraine chronification and reversal
Recipient
Washington University
Award Amount
$462,244.00
Ceiling
$462,244.00
Awarded
April 08, 2026
Identifier
5R01NS128080-04
NIH grant awarded to Washington University to study neuro-immune mechanisms in migraine chronification and reversal, focusing on T cells and neuronal sensitivity.
Description
This project aims to elucidate the neuro-immune mechanisms underlying migraine chronification and reversal, focusing on T cell interactions and trigeminal neuron sensitivity. The study involves depleting specific T cell subsets, analyzing cytokine signaling, and investigating CGRP and PACAP peptide expression in trigeminal ganglion neurons.