Award
National Institute of Allergy and Infectious Diseases 1R21AI199320-01
Post-translational modulation of a host purine biosynthetic enzyme by Chlamydia trachomatis
Recipient
University of Nebraska Medical Center, Omaha, NE, United States
Award Amount
$417,845.00
Ceiling
$417,845.00
Awarded
June 03, 2026
Identifier
1R21AI199320-01
Research project funded by NIAID to study how Chlamydia trachomatis modulates the host enzyme IMPDH2 involved in GTP biosynthesis, to understand host-pathogen interactions and nutritional immunity.
Description
The project investigates how Chlamydia trachomatis, an obligate intracellular pathogen, manipulates host GTP biosynthesis, specifically through modulation of the enzyme IMPDH2, which is involved in GTP synthesis. The study aims to elucidate the molecular mechanisms of chlamydial modulation of IMPDH2 filamentation and how host cytokines influence this process, contributing to the understanding of host-pathogen interactions and nutritional immunity.