Award
National Heart, Lung, and Blood Institute 2R01HL134935-05A1
Role of fibronectin in the morphogenesis of the cardiac outflow tract
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$578,421.00
Ceiling
$578,421.00
Awarded
May 07, 2026
Identifier
2R01HL134935-05A1
This NIH-funded research project aims to understand how fibronectin regulates the development of the cardiac outflow tract, a key factor in congenital heart disease, to improve prenatal screening and therapies.
Description
The project investigates the role of fibronectin (Fn1) and Tenascin C (TnC) in regulating epithelial organization, cell shape, and mechanotransduction in the second heart field (SHF), which are critical for cardiac outflow tract (OFT) elongation and arterial morphogenesis. The goal is to identify molecular candidates for prenatal screening and therapeutic intervention for congenital heart disease (CHD).