Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD108156-04
Discovery Pipeline for Genetic Defects in Hypothalamic-pituitary Development Using International Mouse Phenotyping Consortium Mice
Recipient
University of Michigan at Ann Arbor, MI
Award Amount
$632,242.00
Ceiling
$632,242.00
Awarded
May 04, 2026
Identifier
5R01HD108156-04
A research project funded by NICHD to study genetic defects in hypothalamic-pituitary development using mouse models, aiming to improve molecular diagnosis and understanding of congenital hypopituitarism.
Description
This project involves detailed phenotyping of 18 embryonic lethal or sub-viable mouse lines with hypothalamic and/or pituitary malformations to expand molecular diagnoses and understand organogenesis. The study includes phenotyping mouse strains through histology, scRNA-seq, and mechanistic assays, aiming to establish genotype-phenotype relationships for candidate genes. Data will be shared via existing databases and the IMPC website, with future expansion plans.