Award
California Department of Veterans Affairs 5I01BX005854-04
Foundational Research to Act Upon and Resist Conditions unfavorable to bone (FRACTURECURB): Role of abaloparatide for fracture healing
Recipient
Veterans Affairs Medical Center San Francisco
Awarded
October 03, 2025
Identifier
5I01BX005854-04
This award funds research to study how abaloparatide aids fracture healing by investigating molecular and cellular mechanisms in bone repair, focusing on three types of bone healing sites.
Description
The project aims to determine the effectiveness of abaloparatide in fracture repair, examining cellular and molecular mechanisms, and exploring the roles of IGF1 and ephrinB2/EphB4 signaling in mediating these actions. It focuses on three sites of fracture repair in long bones: intramembranous, endochondral, and intramedullary, hypothesizing that abaloparatide promotes coordinated repair via mechanisms involving IGF1 and ephrinB2/EphB4 signaling.