Award
National Institute of General Medical Sciences 5R35GM153501-02
Cytokinesis and the Septin Cytoskeleton
Recipient
University of Pennsylvania
Award Amount
$743,813.00
Ceiling
$743,813.00
Awarded
August 21, 2025
Identifier
5R35GM153501-02
NIH grant awarded to University of Pennsylvania for research on cytokinesis and septin cytoskeleton mechanisms using advanced imaging and structural techniques to understand cell division and related diseases.
Description
This project focuses on understanding the mechanisms of cytokinesis and the septin cytoskeleton, which are crucial for cell division and are implicated in various diseases including cancer, infertility, and neurodegenerative disorders. The research will utilize budding yeast, fission yeast, and mammalian cells, employing advanced structural and imaging techniques such as super-resolution microscopy, cryo-EM, and AlphaFold2-based predictions.