Award
NIH Reporter #11376299
Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction
Recipient
University of Pennsylvania
Award Amount
$91,704.00
Ceiling
$91,704.00
Awarded
August 26, 2025
Identifier
11376299
The award supports the development of optogenetic tools to control RhoA signaling for studying cell mechanics and signaling pathways, enhancing understanding of cell contractility, motility, and mechanotransduction.
Description
This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.