Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 4R00HD109370-02
Reprogramming Double Negative T Cells to Combat Autoimmune Ovarian Failure and Ovarian Tumors
Recipient
University of Florida
Award Amount
$248,976.00
Ceiling
$248,976.00
Awarded
April 10, 2026
Identifier
4R00HD109370-02
NIH-funded research to study and engineer double-negative T cells for treating autoimmune ovarian failure and ovarian tumors, aiming to develop novel immunotherapies.
Description
This NIH-funded project focuses on understanding and reprogramming T cells to treat ovarian autoimmune failure and tumors, with potential for innovative immunotherapies and women’s health improvements. The project will reveal how DNT cells preserve ovarian immune balance, prevent autoimmunity, and can be engineered for ovarian tumor suppression, leading to new cell-based off-the-shelf treatments for autoimmune ovarian dysfunction and ovarian cancer.