Award
National Institute of General Medical Sciences 5R16GM145484-04
Role of the transcriptional corepressor TLE1 in the lung adenocarcinoma aggressiveness and progression
Recipient
Xavier University of Louisiana
Award Amount
$146,314.00
Ceiling
$146,314.00
Awarded
May 02, 2025
Identifier
5R16GM145484-04
This NIH-funded project studies the transcriptional corepressor TLE1 as a potential therapeutic target in lung adenocarcinoma, focusing on its role in tumor progression and metastasis.
Description
The project investigates the role of the transcriptional corepressor TLE1 in promoting aggressiveness and progression of lung adenocarcinoma (LUAD). It aims to evaluate TLE1's role in tumorigenesis, characterize its transcriptional network, and assess its impact on tumorigenicity and metastasis in mouse models.