Award
National Institute of Environmental Health Sciences 5R44ES035657-03
Triage of Developmental and Reproductive Toxicants using an In vitro to In Vivo Extrapolation (IVIVE)-Toxicokinetic Computational modeling Application
Recipient
SCITOVATION, LLC
Award Amount
$983,133.00
Ceiling
$983,133.00
Awarded
May 13, 2026
Identifier
5R44ES035657-03
The award supports the development of a computational application, DRIIVE, to perform in vitro to in vivo extrapolation using PBPK modeling to assess developmental and reproductive toxicants, aiming to reduce animal testing and improve regulatory decision-making.
Description
This project aims to reduce reliance on animal testing by developing computational models for developmental and reproductive toxicity assessment, facilitating regulatory decision-making, and advancing NAMs in toxicology. It involves developing and validating NAMs combining in vitro reproductive assays with a web-based graphical interface, incorporating a three-tiered PBPK model to predict human equivalent developmental toxicity doses, conducting software validation and retrospective chemical space analysis, and providing a user-friendly interface for regulatory and research use.