Award
National Heart, Lung, and Blood Institute 1R35HL184266-01
Bridging the gap between basic and clinical research to prevent cardiovascular disease in diabetes
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$1,233,682.00
Ceiling
$1,233,682.00
Awarded
March 16, 2026
Identifier
1R35HL184266-01
Research project funded by NHLBI to develop new metrics and prevention strategies for cardiovascular disease in youth with diabetes, focusing on APOC3 and triglyceride-rich lipoproteins.
Description
This project aims to establish new metrics to predict cardiovascular disease risk in youth with diabetes and to identify novel prevention strategies. It focuses on the role of triglyceride-rich lipoproteins and apolipoprotein C3 (APOC3) in cardiovascular risk, especially in youth with T1D and T2D. The research involves longitudinal and mechanistic studies, mouse models, and cell systems to fill gaps in understanding how diabetes promotes CVD risk and to develop new treatments.