Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK139207-03
Deciphering Pancreatitis Microenvironment through Intravital Imaging
Recipient
Mayo Clinic Jacksonville
Award Amount
$578,659.00
Ceiling
$578,659.00
Awarded
April 08, 2026
Identifier
5R01DK139207-03
A research grant awarded to study the mechanisms of acute pancreatitis and develop targeted therapies using advanced imaging and drug delivery systems.
Description
This project aims to investigate the roles of trypsin and coagulation in acute pancreatitis (AP), focusing on thrombin's role via PAR receptors. Using models, inhibitors, and advanced imaging, the study seeks to understand disease mechanisms and develop targeted therapies, including drug delivery enhancements with dabigatran and prodrugs.