Award
National Institute of Allergy and Infectious Diseases 5R21AI183670-02
T Cell Epigenomic Drivers of Disease Flares in Multiple Sclerosis
Recipient
Benaroya Research Institute at Virginia Mason, Seattle, WA
Award Amount
$216,625.00
Ceiling
$216,625.00
Awarded
April 16, 2025
Identifier
5R21AI183670-02
Research project funded by NIAID to study epigenomic changes in T cells that drive disease flares in multiple sclerosis, aiming to uncover molecular mechanisms and potential therapeutic targets.
Description
This project focuses on understanding how changes in chromatin accessibility affect T cell function and lead to disease flares in relapsing-remitting multiple sclerosis (RRMS). The study involves epigenomic analysis of CD4 T cells, including DNA methylation, open chromatin, and histone modifications, in longitudinal cohorts of RRMS patients. The research aims to identify factors that promote disease flares and the molecular mechanisms involved, with a particular focus on the ZFP36L2 gene locus.