Award
National Institutes of Health 11259421
Targeting transcription and translation of the antisense CCCCGG repeat expansion in C9ORF72 ALS/FTD
Recipient
Schools of Medicine in Illinois, United States
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
December 16, 2025
Identifier
11259421
Research project awarded to study and target antisense repeat RNA in C9ORF72 ALS/FTD to find new therapeutic targets using advanced genetic techniques.
Description
This project focuses on studying and targeting the antisense repeat RNA in C9ORF72-related ALS/FTD, utilizing techniques such as CRISPR/Cas9 mutagenesis, CRISPR interference, and antisense oligonucleotides. The goal is to identify new therapeutic targets for neurodegenerative diseases caused by bidirectionally-transcribed repeat expansions.