Award
National Cancer Institute 5R01CA301637-02
The role of early oncogenic drivers in maintaining lineage fidelity in prostate cancer
Recipient
Weill Medical College of Cornell University
Award Amount
$656,000.00
Ceiling
$656,000.00
Awarded
May 04, 2026
Identifier
5R01CA301637-02
A research project funded by the National Cancer Institute to study molecular mechanisms of prostate cancer resistance, focusing on SPOP mutations and their role in disease progression and treatment resistance.
Description
This project aims to define the propensity of prostate cancers harboring SPOP mutations to progress to specific subtypes of treatment-resistant castration-resistant prostate cancer (CRPC), and to elucidate the mechanisms shaping these resistance patterns. Using novel models and human samples, the study will investigate how SPOP mutations reprogram AR function, altering chromatin accessibility and transcription, and how drivers like N-Myc and RB1-loss influence disease progression. The findings will inform precision clinical trials.