Award
National Institute of Allergy and Infectious Diseases 5R01AI175212-03
Role of T-bet B cells in rheumatoid arthritis
Recipient
University of Rochester, School of Medicine & Dentistry
Award Amount
$711,221.00
Ceiling
$711,221.00
Awarded
December 23, 2025
Identifier
5R01AI175212-03
NIH awarded a research grant to study the role of T-bet expressing B cells in rheumatoid arthritis, aiming to uncover their contribution to disease activity and joint damage, potentially leading to new therapies.
Description
This NIH research grant focuses on the role of a novel subset of B cells expressing the transcription factor T-bet in rheumatoid arthritis. The project aims to understand how these cells contribute to ongoing disease activity, inhibit bone-forming osteoblasts, activate bone-eroding osteoclasts, and thus contribute to inflammation and joint destruction. The research involves translational and preclinical studies including patient cohorts, single-cell transcriptomics, spatial analysis, and animal models to explore mechanisms of joint erosion and inflammation.