Award
NIH Reporter #4U01CA294552-02
Pediatric Solid Tumor Microenvironment Atlas
Recipient
National Cancer Institute (NCI)
Award Amount
$4,528,480.00
Ceiling
$4,528,480.00
Awarded
September 15, 2025
Identifier
4U01CA294552-02
Award to develop a Pediatric Solid Tumor Microenvironment Atlas using advanced spatial omics technologies to improve understanding and treatment of childhood solid tumors.
Description
This project aims to create a Pediatric Tumor Microenvironment Atlas focusing on childhood solid tumors such as rhabdomyosarcoma, Wilms tumor, and neuroblastoma. Using spatial transcriptomic and proteomic technologies, the project will classify immune and non-immune cells, compare diagnostic samples among responders and non-responders, and evaluate therapy effects on the tumor microenvironment (TME) and lineage plasticity. The goal is to identify shared pathways and networks across pediatric tumors to develop novel immunotherapy approaches, improve outcomes, and reduce long-term toxicities.