Award
NIH Reporter #1F31HL180024-01
Deciphering the role of regulatory T cell derived Mmp12 in lung injury resolution
Recipient
University of North Carolina at Chapel Hill
Award Amount
$39,023.00
Ceiling
$39,023.00
Awarded
August 26, 2025
Identifier
1F31HL180024-01
The award supports research to understand how regulatory T cell-derived Mmp12 contributes to lung injury resolution, with the goal of developing novel therapies for ARDS by clarifying Treg mechanisms and identifying key substrates involved in lung repair.
Description
This project aims to elucidate the role of Treg-derived Mmp12 in lung injury resolution and identify its substrates to facilitate therapeutic development for Acute Respiratory Distress Syndrome (ARDS). The study will use mice models to determine the function of Treg-derived Mmp12 in resolving inflammation during acute lung injury induced by LPS or influenza, identify substrates of extracellular Treg-derived Mmp12, and broaden understanding of Treg biology and function during lung repair.