Award
National Institute of General Medical Sciences 5R35GM158228-02
Coordinated Control of Metabolism by Enzymes and Transporters
Recipient
Brown University, Providence, RI, United States
Award Amount
$398,750.00
Ceiling
$398,750.00
Awarded
June 19, 2026
Identifier
5R35GM158228-02
The award supports research on the coordination between transporters and enzymes in metabolism, particularly the transport and regulation of nicotinamide (NAM) related to NAD metabolism, with implications for aging and disease.
Description
This research program aims to mechanistically define how transporters and enzymes interact to maintain metabolic balance, focusing on the regulation of NAD metabolism, specifically the transport and regulation of nicotinamide (NAM) in mammalian cells. The project seeks to develop genetic and pharmacological tools based on mechanisms of NAM transport.