Award
National Cancer Institute 4R01CA266187-04
DIRAS3 disrupts K-RAS clustering and signaling, enhancing autophagy and response to autophagy inhibition
Recipient
University of TX MD Anderson Cancer Center
Award Amount
$1,102,724.00
Ceiling
$1,102,724.00
Awarded
September 10, 2025
Identifier
4R01CA266187-04
NIH awarded a multiyear grant of about $1.1 million to study DIRAS3's role in disrupting K-RAS signaling and enhancing autophagy inhibition response in cancer models.
Description
This NIH grant focuses on studying the role of DIRAS3 in targeting KRAS, inducing autophagy, and enhancing response to autophagy inhibitors in pancreatic ductal adenocarcinoma (PDAC) and low-grade serous ovarian cancer (LGSOC). The project involves mechanistic studies and testing of therapeutic peptides in cell and mouse models. The award is multiyear, with a total funding of approximately $1.1 million for fiscal year 2025.