Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 2R01AR072965-06A1
Type I Interferon induction of neuroinflammation mediates neuropsychiatric lupus
Recipient
Boston Children's Hospital, Boston, MA, United States
Award Amount
$1,407,090.00
Ceiling
$1,407,090.00
Awarded
August 18, 2025
Identifier
2R01AR072965-06A1
A research project funded by NIAMS to study how type I interferon-induced neuroinflammation contributes to neuropsychiatric symptoms in lupus, focusing on glial cell activation and neuronal changes, aiming to identify therapeutic targets.
Description
This project aims to test the hypothesis that peripheral and local inflammation promote pathogenic changes in glial cells, leading to connectivity alterations observed in nervous system diseases. The study will identify a novel role for microglia and astrocytes in SLE, providing mechanistic insights and potential therapeutic targets. It involves extensive molecular and cellular analysis, spatial transcriptomics, and investigation of neuroinflammatory mechanisms in lupus models to elucidate the role of interferon signaling in neuropsychiatric manifestations of lupus and identify potential therapeutic targets.