Award
National Institute of General Medical Sciences 5R01GM144446-04
Drug, Nucleotide, and Lipid Interactions with P-glycoprotein
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$302,415.00
Ceiling
$302,415.00
Awarded
May 07, 2025
Identifier
5R01GM144446-04
NIH awarded a research project to University of Washington to study P-glycoprotein interactions using advanced methods to understand drug resistance.
Description
This project focuses on the conformational dynamics of P-glycoprotein, its sensitivity to lipid environment, and its substrate promiscuity, utilizing advanced kinetic and spectroscopic methods. This NIH project involves advanced research on P-glycoprotein, including kinetic modeling, hydrogen/deuterium exchange mass spectrometry, and single-molecule fluorescence techniques to understand drug resistance mechanisms.