Award
National Institute of General Medical Sciences 5R35GM150992-03
Mechanistic insights into translesion synthesis-dependent genome instability
Recipient
University of Vermont & St. College
Award Amount
$378,240.00
Ceiling
$378,240.00
Awarded
July 28, 2025
Identifier
5R35GM150992-03
NIH grant awarded to University of Vermont & St. College to study the multifaceted role of REV1 polymerase in genome instability and its implications for human disease.
Description
This NIH grant project aims to understand the molecular mechanisms by which the REV1 polymerase controls genome stability and its broader roles beyond translesion synthesis, including regulation of autophagy, metabolic processes, mitosis fidelity, and replication stress through rereplication.