Award
NIH Reporter #5R56AG084730-02
Optimization of a potent and cell active CK2 chemical probe for Alzheimer's disease therapy
Recipient
UNIV OF NORTH CAROLINA CHAPEL HILL
Award Amount
$796,443.00
Ceiling
$796,443.00
Awarded
August 04, 2025
Identifier
5R56AG084730-02
Award for developing a chemical probe targeting CK2 enzyme to advance Alzheimer's disease therapy through medicinal chemistry and biological validation.
Description
This project aims to develop a potent, selective, and cell-active chemical probe targeting the enzyme CK2 for Alzheimer's disease therapy. The research involves medicinal chemistry, in vivo validation in a 3xTg mouse model, and profiling in stem cell-based assays to understand CK2's role in neuroinflammation and neurodegeneration.