Award
National Institute of Allergy and Infectious Diseases 5F30AI181515-03
Characterization of Enterovirus 68 3C Protease For the Development of Robust and Potent Direct-Acting Antiviral Inhibitors
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$58,114.00
Ceiling
$58,114.00
Awarded
December 16, 2025
Identifier
5F30AI181515-03
The award supports research to develop robust antiviral inhibitors against Enterovirus 68 by studying the 3C protease structure and designing compounds less susceptible to drug resistance.
Description
This project aims to develop antiviral inhibitors targeting EV68 3C protease using structural biology techniques, including crystallography, to create resistance-resistant antiviral compounds. The study involves determining cocrystal structures of EV68 3C protease with viral substrates to inform the design of robust pan-3C-protease inhibitors and testing novel direct-acting antivirals (DAAs).