Award
National Institute of Allergy and Infectious Diseases 1R21AI190446-01
Mechanisms by which Glp-1 and Gip receptor signaling enhance airway epithelial barrier function
Recipient
Vanderbilt University Medical Center
Award Amount
$481,249.00
Ceiling
$481,249.00
Awarded
July 17, 2025
Identifier
1R21AI190446-01
The award funds research to establish proof-of-concept that dual GLP1R/GIPR signaling improves airway epithelial cell barrier function and anti-viral immune responses to respiratory syncytial virus, aiming to reduce viral-induced asthma exacerbations.
Description
This project aims to determine the direct actions of glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling on the human airway epithelium response to respiratory syncytial virus, to optimize the use of GLP1R agonists and dual GLP1R/GIPR agonists to prevent viral-induced exacerbations in asthma.