Award
National Institute on Aging 5R01AG084804-03
Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$398,251.00
Ceiling
$398,251.00
Awarded
February 25, 2026
Identifier
5R01AG084804-03
Award for research developing novel single-cell mass cytometry methods to study aging mechanisms in murine liver models, focusing on metabolic processes and senescence.
Description
This project aims to develop single-cell and imaging methods using metal-bearing probes to monitor metabolic processes in live cells, such as siRNA delivery, protein synthesis, and post-translational modification. The research will explore the relationship between autophagy, mevalonate pathway, and senescence in murine liver models to understand aging mechanisms and inform treatments.