# NIH Reporter #5K08CA279499-04

Targeting regenerative reprogramming in colorectal cancer

**Recipient:** University of Texas MD Anderson Cancer Center

**Award Amount:** $292,594.00
**Ceiling:** $292,594.00

**Awarded:** August 20, 2026

**Identifier:** 5K08CA279499-04

The project investigates preexisting cancer-cell states and epigenetic adaptations that enable therapy resistance in colorectal cancer. It will use lineage tracing, single-cell technologies, patient-derived organoids, and screening of chromatin regulators to identify and test potential treatments.

### Description

NIH award supporting research into how colorectal cancer cells develop treatment resistance through regenerative reprogramming, and approaches to reverse these adaptations.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11384644)