Award
NIH Reporter #1R03DK149104-01
Structure-guided approaches to prevent polymyxin-induced acute kidney injury
Recipient
Columbia University Health Sciences
Award Amount
$123,375.00
Ceiling
$123,375.00
Awarded
August 20, 2026
Identifier
1R03DK149104-01
Research project funded by NIDDK to study and prevent polymyxin-induced acute kidney injury by identifying inhibitors that block the drug's nephrotoxic effects while preserving its antimicrobial activity.
Description
The project aims to uncouple polymyxin’s antimicrobial activity from its renal toxicity by defining the structural basis for the LRP2-polymyxin interaction and identifying competitive inhibitors using structural techniques such as cross-linking mass spectrometry and cryo-electron microscopy. The goal is to develop a therapy to protect kidney function during polymyxin treatment.