Award
National Institute of Neurological Disorders and Stroke 5R01NS073899-14
The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function
Recipient
University of South Florida
Award Amount
$678,953.00
Ceiling
$678,953.00
Awarded
February 25, 2026
Identifier
5R01NS073899-14
Research project funded by the National Institute of Neurological Disorders and Stroke to study the role of FKBP51 in tau protein regulation and neuropsychiatric symptoms in Alzheimer's disease, aiming to validate FKBP51 as a therapeutic target.
Description
This project aims to validate FKBP51 as a therapeutic target for tau-related neurodegeneration and to explore the molecular mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease. The research will use transgenic mouse models to study the role of FKBP51 in tau accumulation and neuropsychiatric symptoms in Alzheimer's disease.