Award
NIH Reporter #3R01AI168238-05S1
Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine Candidates
Recipient
Yale University
Award Amount
$104,466.00
Ceiling
$104,466.00
Awarded
July 16, 2026
Identifier
3R01AI168238-05S1
This award funds research to evaluate how genetic diversity affects malaria vaccine candidates by creating transgenic parasites and using genomic and structural biology approaches to improve vaccine discovery.
Description
The project aims to address the extensive antigenic diversity of Plasmodium falciparum by utilizing genomic resources and targeted genome editing (CRISPR/Cas9) to evaluate vaccine candidates, including PfRh5. The study will create transgenic parasites to assess the role of genetic diversity in immune evasion and vaccine efficacy, using IgG from malaria-immune individuals and vaccine trial subjects.