Award
National Institute of Environmental Health Sciences 1R21ES037451-01
The role of the epicardium and IRE1 in mediating environmental exposure on cardiac function
Recipient
Michigan State University, East Lansing, MI, United States
Award Amount
$100,000.00
Ceiling
$100,000.00
Awarded
September 27, 2025
Identifier
1R21ES037451-01
This award supports research on the impact of PFAS exposure on cardiac function mediated by IRE1 signaling and epicardial cells using human heart organoids.
Description
The project investigates how environmental chemicals, specifically PFAS, affect cardiac function via ER stress pathways, using human organoids to study lipid profile changes and the role of epicardial cells.