Award
National Institute of Mental Health 1K01MH139990-01A1
Projection-specific mechanisms mediating postpartum stress effects on the maternal brain
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, UNITED STATES
Award Amount
$717,688.00
Ceiling
$717,688.00
Awarded
March 19, 2026
Identifier
1K01MH139990-01A1
Award to study how postpartum stress and parity affect maternal brain vulnerability through epigenetic mechanisms, using a novel mouse model to understand maternal mental health risks.
Description
This K01 proposal aims to delineate the beneficial effects of parity alone versus the maladaptive effects of its interaction with postpartum stress on maternal susceptibility, focusing on projection-specific epigenetic mechanisms within the brain. Using a novel mouse model and cutting-edge approaches, this proposal promises to elucidate the lifelong impact of prior reproductive experiences and stress, providing new insights into the complex mechanisms underlying maternal mental health vulnerability.