Award
National Institute of General Medical Sciences 5R35GM118141-10
Mitochondrial Biogenesis in Health and Disease
Recipient
University of Miami School of Medicine, Coral Gables, FL, United States
Award Amount
$921,456.00
Ceiling
$921,456.00
Awarded
August 05, 2025
Identifier
5R35GM118141-10
This award funds research to understand mitochondrial membrane biogenesis and assembly of oxidative phosphorylation complexes, addressing mitochondrial disorders through advanced genetic and biochemical methods.
Description
The project aims to develop a research program focused on understanding the biogenesis of mitochondrial membranes, particularly oxidative phosphorylation (OXPHOS) enzymes, supercomplexes, mitoribosomes, and mitochondrial translation machinery in yeast and human cells. The research addresses disorders related to mitochondrial OXPHOS function and gene expression, including neurodegeneration, metabolic diseases, cancer, and aging. The study involves yeast genetics, gene disruption in human cells using gene-editing strategies, cryo-EM reconstruction, and mechanistic biochemistry to elucidate the roles of assembly factors in mitochondrial complex and ribosome assembly.