Award
National Institute of Allergy and Infectious Diseases 5R01AI167058-05
Mechanisms and consequences of extrafollicular B cell activation during malaria
Recipient
University of Iowa
Award Amount
$647,119.00
Ceiling
$647,119.00
Awarded
August 08, 2025
Identifier
5R01AI167058-05
Research project funded by NIH to understand and improve humoral immunity against malaria by studying B cell activation and immune memory affected by Plasmodium infection.
Description
This project aims to define mechanisms that trigger immune dysregulation during malaria and study the long-term consequences of these events. It investigates how Plasmodium parasites co-opt and subvert humoral immunity, focusing on polyclonal B cell activation and its impact on immune memory. The research explores molecular and cellular mechanisms governing immunosuppressive B cell expansion and their effects on memory B cell programming, with the goal of improving humoral immunity against malaria.