Award
National Institute of Allergy and Infectious Diseases 1R21AI199908-01
Combining CRISPR-Cas9 base editing and proteomics to determine how filovirus VP24 proteins modulate ubiquitination and viral replication
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, USA
Award Amount
$462,000.00
Ceiling
$462,000.00
Awarded
June 16, 2026
Identifier
1R21AI199908-01
This award funds research using CRISPR-Cas9 and proteomics to study how filovirus VP24 proteins affect ubiquitination and viral replication, aiming to understand virus evolution and virulence.
Description
The study compares Marburg virus (MARV) and Měnglà virus (MLAV) VP24 proteins for their capacity to modulate cellular ubiquitination pathways, providing insights into filovirus evolution, virulence, and zoonotic potential. It involves proteomics, mutational mapping, CRISPR-Cas9 gene editing, and viral replication modeling.