Award
National Institute of Neurological Disorders and Stroke 5R01NS141137-02
Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease
Recipient
University of Miami Coral Gables
Award Amount
$603,840.00
Ceiling
$603,840.00
Awarded
August 20, 2025
Identifier
5R01NS141137-02
This NIH grant funds research on how neutrophils contribute to vascular inflammation in vascular dementia and mixed Alzheimer's disease, using mouse models to study blood flow, molecular changes, and potential interventions.
Description
The project examines mouse models of vascular dementia and Alzheimer’s disease over time to investigate the role of white blood cells in vascular damage, molecular changes in white blood cells, and their contribution to neurodegenerative diseases. It aims to identify stage-specific biomarkers and elucidate the role of activated neutrophils in VCID and mixed AD.