Award
NIH Reporter #5R01AG089192-03
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Recipient
Florida Institute / Human / Machine Cognition, Pensacola, FL, United States
Award Amount
$1,503,097.00
Ceiling
$1,503,097.00
Awarded
August 07, 2026
Identifier
5R01AG089192-03
This award funds a project to understand the biological and behavioral mechanisms behind the variability in exercise response among older adults, using combined endurance and resistance training and advanced predictive modeling to improve health outcomes.
Description
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercise responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult’s capacity to attain the many health benefits of exercise.