National Institute on Aging 4R00AG081495-03

A multi-omic and integrative longitudinal evaluation of the role of lipid, antioxidant, and osmoprotectant metabolites in the genitourinary syndrome of menopause by race and ethnicity.

This award funds a research project investigating the role of various metabolites in the genitourinary syndrome of menopause, focusing on racial and ethnic disparities, using multi-omics and machine learning methods to develop targeted interventions.

Description

The project focuses on the genitourinary syndrome of menopause (GSM), a chronic urogenital and sexual condition affecting postmenopausal women, with disproportionate impact on racial and ethnic minorities. It aims to understand the complex interactions of lipid, antioxidant, and osmoprotectant metabolites through multi-omics approaches, machine learning, and structural models. The study leverages a large longitudinal cohort of 500 participants, including 25% racial/ethnic minorities, with samples sent for microbiome, metabolomic, and cytokine profiling. The research will inform targeted interventions such as antioxidant therapy and contribute to developing personalized management strategies for GSM.

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