Award
National Cancer Institute 5R01CA259037-05
Tuning PARP-1 retention and release on DNA breaks
Recipient
University of Pennsylvania
Award Amount
$450,488.00
Ceiling
$450,488.00
Awarded
March 03, 2026
Identifier
5R01CA259037-05
The award supports research on PARP-1's role in DNA repair and cancer therapy development through biochemical and medicinal chemistry approaches.
Description
This project aims to understand PARP-1 activation, regulation, and inhibition mechanisms, develop small molecule tools, and explore imaging approaches for cancer therapy. It focuses on understanding the molecular mechanisms of PARP-1 in DNA repair and developing targeted cancer therapies using small molecules and imaging techniques.