Award
National Institute of Allergy and Infectious Diseases 5R01AI185073-03
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
Recipient
Albert Einstein College of Medicine
Award Amount
$726,996.00
Ceiling
$726,996.00
Awarded
July 15, 2026
Identifier
5R01AI185073-03
NIH funded research project to study the structure and function of Crimean-Congo hemorrhagic fever virus glycoproteins, focusing on virus assembly, entry, pathogenesis, and antibody development.
Description
The project aims to study the structure, assembly, and function of glycoproteins of the Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne virus causing severe hemorrhagic disease in humans. The research will focus on high-resolution structures of glycoprotein complexes, mechanisms of virus assembly and entry, and the development of monoclonal antibodies for medical countermeasures.