Award
National Institute of Allergy and Infectious Diseases 1R01AI191355-01A1
Bacterial lipases and adaptation to the host lipid environment
Recipient
UNIVERSITY OF ILLINOIS AT CHICAGO
Award Amount
$736,822.00
Ceiling
$736,822.00
Awarded
January 30, 2026
Identifier
1R01AI191355-01A1
Research project studying the role of S. aureus secreted lipases in immune evasion, nutrient acquisition, infection persistence, and adaptation to host lipids.
Description
This project involves mechanistic studies of S. aureus secreted lipases, focusing on their role in immune evasion, nutrient acquisition, and infection persistence. The project aims to test the roles of three lipases in virulence, lipid utilization, and immune defense, and to understand how lipases disrupt immunity and facilitate adaptation to circulating lipids in the host.