Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK113080-08
Understanding Mechanisms that Regulate Liver Growth and Function
Recipient
University of Illinois at Urbana-Champaign
Award Amount
$454,537.00
Ceiling
$454,537.00
Awarded
June 01, 2026
Identifier
5R01DK113080-08
Research project funded by NIDDK to study liver growth and function regulation, focusing on nuclear receptor CAR's role in metabolism and regeneration, including sex differences and molecular mechanisms.
Description
The project investigates the regulation of liver growth and function, focusing on the role of the nuclear receptor CAR in sex-specific and spatiotemporal metabolic processes during liver injury and regeneration. It aims to understand CAR's influence on zonation, polyploidy, injury response, and interaction with estrogen receptor α, using high throughput transcriptome and cistrome analyses.