Award
National Institute of General Medical Sciences 5R35GM149337-04
A translational approach to predicting small molecule drug permeation through microneedle-treated skin
Recipient
UNIVERSITY OF IOWA
Award Amount
$399,104.00
Ceiling
$399,104.00
Awarded
July 15, 2026
Identifier
5R35GM149337-04
This NIH grant supports research to understand and predict how small molecule drugs permeate through microneedle-treated skin, involving both laboratory and clinical studies to identify key factors affecting drug absorption and transport.
Description
The project focuses on investigating how chemical properties of drug compounds affect absorption through microneedle-treated skin. The research includes in vitro permeation tests and in vivo pharmacokinetics studies in animals and humans. The project aims to identify key physicochemical properties impacting permeability and flux. The work supports the NIGMS mission in drug delivery, absorption, transport, and kinetics.