Award
NIH Reporter #1R21DE033458-01A1
Health-associated oral bacteria as anti-cancer and immunomodulatory agents in oral cancer
Recipient
Temple University of the Commonwealth
Award Amount
$469,830.00
Ceiling
$469,830.00
Awarded
September 16, 2024
Identifier
1R21DE033458-01A1
Award for research on using oral bacteria as anti-cancer and immunomodulatory agents in oral cancer, conducted by Temple University with a focus on oral squamous cell carcinoma and immunotherapy response.
Description
The project focuses on investigating the impact of two commensal bacterial species found in the oral cavity on the development of oral cancer and its response to immunotherapy in mice. The study employs various technologies including digital imaging, histopathology, immunohistochemistry, flow cytometry, q-PCR, fluorescent in-situ hybridization, and RNA sequencing. The project aims to explore the use of health-associated bacteria as anticancer and immunomodulatory agents in oral squamous cell carcinoma (OSCC). Local delivery methods such as gel, mouthwash, or lozenge may be used in human subjects for prevention or as an adjunctive therapy.