National Institute of Allergy and Infectious Diseases 5R01AI099108-14

Transcriptional Regulation of Antibody Responses and Immunity

NIH awarded a research grant to the University of Arizona to study the molecular and genetic factors controlling the duration of antibody-mediated immunity, aiming to improve vaccine strategies.

Description

This is a multi-year NIH research project focused on immunology and vaccine response, employing advanced molecular and genetic techniques. The project aims to define molecular programs and cellular trajectories leading to long-lived plasma cells and to identify transcriptional and epigenetic features of memory B cells that precede durable recall responses. The study will employ transcription factors, single-cell transcriptional and epigenetic profiling, and genetic tools to manipulate genes in vivo, with the goal of predicting and optimizing humoral immunity.

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