Award
National Institute on Aging 1R21AG100967-01
Defining Characteristics of a Resilient Organelle Interactome During Aging
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$435,875.00
Ceiling
$435,875.00
Awarded
May 12, 2026
Identifier
1R21AG100967-01
Research project funded by the National Institute on Aging to study organelle interactions and metabolic resilience during aging using advanced microscopy and AI in Caenorhabditis elegans.
Description
This project investigates how organelles interact and reorganize within aging cells, influencing metabolic resilience. It aims to uncover new targets for preventing or delaying age-related diseases through regulation of subcellular architecture. Using advanced 3D electron microscopy and AI-based image analysis in the model organism Caenorhabditis elegans, the study will map organelle interactions, compare age-dependent changes under different lifespan-extending interventions, and develop genetic tools to manipulate organelle contact sites.